6 thoughts on “Päivän kuva: Tehosterokote

  1. 20.10.2017 "Tutkijoiden mukaan iso osa viime vuosikymmenten biolääketieteellisestä tutkimuksesta voi osoittautua kelvottomaksi niihin sisältyvän järjestelmällisen ongelman takia." sanoo:

    https://yle.fi/uutiset/3-9886560
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    ”Pahimmissa tapauksessa on esimerkiksi luultu tutkittavan ihmisen syöpäsoluja, vaikka enemmistö soluista onkin peräisin hiireltä. Tuloksena voi olla tieteellisiä artikkeleita, joissa raportoidaan ihmisen ihosyöpään liittyvistä löydöistä, vaikka päätelmät on tehty hiiren soluja tutkimalla.” ”Usein tutkijat eivät edes huomaa virhettä.” ”Ongelma on, että tutkimusdata voi olla kelvotonta”🐭🧬🤢
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    ”työntekijät tuntevat ongelman, mutta sanovat, ettei kukaan kuuntele heitä. He ovat vihaisia”
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    ”netissä on sivustoja, joilta voi tarkistaa, onko solulinja sitä mitä sen pitäisi olla, vai onko se vikamääriteltyjen joukossa”🦠
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    https://www.sciencedirect.com/topics/neuroscience/cell-lines
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    ”A.B. Ulrich, P.M. Pour, in Encyclopedia of Genetics, 2001”: ”The resulting genetic manipulations limit the use of these cells for molecular biological studies, especially for defining genetic changes that occur during cell differentiation and transformation. The introduction of these foreign genes alters the function of the host’s regulatory genes including the inactivation of the tumor suppressor protein p53 and retinoblastoma protein pRb.”🧬
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    https://wwwnc.cdc.gov/eid/article/12/1/05-0496_article
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    ”Volume 12, Number 1—January 2006 ”: ”The most probable sources of future infections are exposure to animal reservoirs or laboratories where SARS-CoV is manipulated for research purposes. Indeed, since the first epidemic, SARS has occurred on 3 occasions as a result of breaches in laboratory biosafety procedures (11–13). This finding highlights the importance of safely handling SARS-CoV, especially in diagnostic virology laboratories where virus isolation is performed and in research laboratories where infectious virus is handled.”🦠🧬
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    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778494/
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    ”Eur J Clin Microbiol Infect Dis. 2021 Jan 2 : 1–8.”: ”Coronaviruses are enveloped, positive single-stranded large RNA viruses that infect also a wide range of animals. The first description of coronavirus was made in 1966 by Tirell and Bynoe, who cultivated the viruses from patients with colds. They were named coronavirus because of their morphology, spherical virions with a core shell and surface resembling to a solar crown, in Latin corona. Coronaviruses are divided into 4 subfamilies alpha, beta, delta and gamma-coronaviruses. The first two originate from mammals, in particular bats, while the other two come from pigs and birds. The genome size of coronaviruses ranges from approximately 27 to 34 kilobases. Severe disease and fatalities are caused essentially by beta-coronaviruses, whereas alpha-coronaviruses cause asymptomatic or mildly symptomatic infections. SARS-CoV and Middle East Respiratory Syndrome coronavirus (MERS-CoV) belong to the beta-coronavirus cluster , as well as the SARS-CoV-2″🦠
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    ”SARS-CoV-2 was isolated on VERO cells, which are kidney epithelial cells extracted from African green monkey”🤢🦠🐵
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    ”kidney cells derived from two species of monkey (African green monkey and rhesus macaque) support the growth of SARS-CoV-2, and all these cells, except for LLC-MK2 cell lines, presented CPE at 48 h post-infection.”🤢🦠🐵

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